The A50 is closed between the A38 and the A6, near Derby, following a serious incident.
A Derbyshire police spokesman said the incident, involving a lorry and a van, happened at 2.30am on the A50.
Firefighters were also called to the scene to release one casualty from the van.
The eastbound carriageway, between junction 4, at Toyota Island in Findern, and junction 2, in Aston-on-Trent, is currently closed.
The Highways Agency said traffic is currently being diverted off the A50 onto the A38 following the 'black square' diversion route, then taking the A52 though Derby to the M1.
Traffic can take M1 south to rejoin A50 at J24A.
There are currently delays of 30 minutes due to congestion, which is backed up to juntion 5, A516, in Etwall.
The Highways Agency has said the road is expected to re-open from 9am.
Police continue to work hard to clear #A50 currently closed btwn #A38#ToyotaIsland and A6. Allow extra travelling time. Diversion in place
— Highways Agency (@HAtraffic_emids) June 30, 2014The #A50 eastbound is closed between the jcts with the #A38 and the #A6 due to a serious accident. Road expected to re-open from 9am.
— East Midland Traffic (@emtrafficnews) June 30, 2014The #A50 eastbound entry slip from the #A38 is closed due to an incident. Road expected to re-open from 9am.
— East Midland Traffic (@emtrafficnews) June 30, 2014